Thermal Perception of Ventilation Changes in Full-Face Motorcycle Helmets: Subject and Manikin Study

We report the effects of full-face motorcycle helmet ventilation systems on heat, airflow, noise, and comfort perception for ventilation changes on the scalp. Eight subjects (aged 28.0 ± 5.4 years) underwent two experimental trials at ambient temperatures of 23.7 ± 0.4°C or 27.5 ± 0.3°C. In each trial, the thermally equilibrated subjects underwent two examination phases, during which four different helmets were assessed at wind speeds of 39.2 ± 1.9 km h−1 and 59.3 ± 1.4 km h−1. Vent-induced heat loss in the scalp ranged from −6.1 to 6.1 W, corresponding to vents being closed or opened, respectively. Perception of vent-induced changes was assessed immediately after the change. We find that the vent-induced heat loss, the subject, and the helmet are the most important response factors. In addition, comparison of two helmets with similar vent-induced heat loss suggests that internal airflow patterns may be important in explaining the observed perception difference

The Effect of Two Sock Fabrics on Perception and Physiological Parameters Associated with Blister Incidence: A Field Study

The goal of the present study was to investigate differences in perception and skin hydration at the foot of two sock fabrics with distinct moisture properties in a realistic military setting. Thirty-seven military recruits wore two different socks (PP: 99.6% polypropylene and 0.4% elastane, and BLEND: 50% Merino-wool, 33% polypropylene, and 17% polyamide), one on each foot. Measurements were carried out after a daily 6.5-km march on 4 days. Each participant rated temperature, dampness, friction, and comfort for each foot. On a daily selection of participants, skin hydration was measured on three sites of both feet using a corneometer, and moisture content of the socks was determined. BLEND was rated to be cooler, less damp, and more comfortable (P < 0.05). Two out of three skin sites were drier for BLEND than PP (P < 0.05). Moreover, BLEND stored 2.9 ± 0.3 times more moisture compared to PP. Thus, under the present conditions, socks such as BLEND are to be preferred over polypropylene sock

Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity

AbstractXenotropic murine leukemia virus-related virus (XMRV) is a novel retrovirus, related to murine leukemia virus (MLV), that has been implicated in human disease. If XMRV is indeed able to replicate in humans, then one might predict that XMRV would have developed resistance to human innate antiviral resistance factors such as APOBEC3G (hA3G). In fact, we observed that XMRV and MLV are both highly sensitive to inhibition by hA3G and equally resistant to inhibition by murine APOBEC3. While several human prostate cancer cell lines were found to lack hA3G, stable expression of physiological levels of hA3G rendered these cells refractory to XMRV replication. Few human tissues fail to express hA3G, and we therefore hypothesize that XMRV replicates in one or more hA3G-negative reservoir tissues and/or that human XMRV infections are likely to be rare and potentially of zoonotic origin

Urban blue space renovation and local resident and visitor well-being:A case study from Plymouth, UK

Observational studies have suggested that people with better access to attractive, safe, and inclusive blue spaces enjoy higher psychological well-being, with particular benefits for those living in deprived urban areas. However, intervention studies are scarce. To help bridge this gap we conducted a repeat cross-sectional study exploring local resident and visitor well-being before and after a small-scale intervention aimed at improving the quality of an urban beach area in a deprived neighbourhood in Plymouth, United Kingdom. Physical alterations were co-created with local stakeholders and residents, and accompanied by a series of on-site community events. Key outcomes were self-reported psychological well-being, satisfaction with personal safety and community belonging, and perceptions of site quality. Adjusted linear models showed that positive well-being (B = 7.42; 95% CI = 4.18–10.67) and life satisfaction (B = 0.40; 95% CI = 0.11–0.70) were both higher after the intervention compared to before, with associations for life satisfaction stronger among those who visited the site in the last four weeks. Associations with positive well-being were partially mediated by greater satisfaction with community belonging; and associations with life satisfaction were partially and independently mediated by greater satisfaction with personal safety and community belonging. Although caution needs to be taken due to the repeat cross-sectional design and the sampling of site visitors as well as local residents, the findings support the idea that environmental improvements to urban blue spaces can foster better psychological well-being, and underline the importance of community involvement in the process

Rehabilitation in patients with radically treated respiratory cancer: A randomised controlled trial comparing two training modalities.

INTRODUCTION: The evidence on the effectiveness of rehabilitation in lung cancer patients is limited. Whole body vibration (WBV) has been proposed as an alternative to conventional resistance training (CRT). METHODS: We investigated the effect of radical treatment (RT) and of two rehabilitation programmes in lung cancer patients. The primary endpoint was a change in 6-min walking distance (6MWD) after rehabilitation. Patients were randomised after RT to either CRT, WBVT or standard follow-up (CON). Patients were evaluated before, after RT and after 12 weeks of intervention. RESULTS: Of 121 included patients, 70 were randomised to either CON (24), CRT (24) or WBVT (22). After RT, 6MWD decreased with a mean of 38m (95% CI 22-54) and increased with a mean of 95m (95% CI 58-132) in CRT (p<0.0001), 37m (95% CI -1-76) in WBVT (p=0.06) and 1m (95% CI -34-36) in CON (p=0.95), respectively. Surgical treatment, magnitude of decrease in 6MWD by RT and allocation to either CRT or WBVT were prognostic for reaching the minimally clinically important difference of 54m increase in 6MWD after intervention. CONCLUSIONS: RT of lung cancer significantly impairs patients' exercise capacity. CRT significantly improves and restores functional exercise capacity, whereas WBVT does not fully substitute for CRT